MF7000825 Mouse mRNA decapping enzyme (DcpS) 1vlr X-ray 1.83 Homodimer Mus musculus 16001405 Han GW, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, Hale J, Hampton E, Haugen J, Hornsby M, Jaroszewski L, Klock HE, Koesema E, Kreusch A, Kuhn P, Lesley SA, McPhillips TM, Miller MD, Moy K, Nigoghossian E, Paulsen J, Quijano K, Reyes R, Spraggon G, Stevens RC, van den Bedem H, Velasquez J, Vincent J, White A, Wolf G, Xu Q, Hodgson KO, Wooley J, Wilson IA Proteins 2005 4 60 797-802 GO:0140932 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity GO:0042802 identical protein binding GO:0000340 RNA 7-methylguanosine cap binding GO:0005737 cytoplasm GO:0005829 cytosol GO:0005739 mitochondrion GO:0005654 nucleoplasm GO:0005634 nucleus GO:0000932 P-body GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0045292 mRNA cis splicing, via spliceosome 2 1 Homooligomeric enzymes Homodimeric enzymes All chains according to the most probable oligomerization state stored in PDBe were considered. A m7GpppX diphosphatase Mus musculus Q9DAR7 38 337 88% MADTAPQLKRKREQEAEEAETPSTEEKEAGVGNGTSAPVRLPFSGFRVQKVLRESARDKIIFLHGKVNEDSGDTHGEDAVVILEKTPFQVEHVAQLLTGSPELKLQFSNDIYSTYNLFPPRHLSDIKTTVVYPATEKHLQKYMRQDLRLIRETGDDYRTITLPYLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILREGQEAILKRYQVTGDRLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAQVIENLECDPKHYQQRTLTFALRTDDPLLQLLQKAQQERN 338 secondary structure helix 101 110 secondary structure helix 132 137 secondary structure helix 147 155 secondary structure helix 165 172 secondary structure helix 172 181 secondary structure helix 184 192 secondary structure helix 240 244 secondary structure helix 245 247 secondary structure helix 248 268 secondary structure helix 270 272 secondary structure helix 309 319 secondary structure helix 321 326 secondary structure helix 336 349 secondary structure strand 59 67 secondary structure strand 72 79 secondary structure strand 89 97 secondary structure strand 114 120 secondary structure strand 124 130 secondary structure strand 138 143 secondary structure strand 159 164 secondary structure strand 202 204 secondary structure strand 211 215 secondary structure strand 228 233 secondary structure strand 274 279 secondary structure strand 288 293 secondary structure strand 306 308 secondary structure strand 328 333 pfam PF11969 Scavenger mRNA decapping enzyme C-term binding 173 291 B m7GpppX diphosphatase Mus musculus Q9DAR7 39 337 88% MADTAPQLKRKREQEAEEAETPSTEEKEAGVGNGTSAPVRLPFSGFRVQKVLRESARDKIIFLHGKVNEDSGDTHGEDAVVILEKTPFQVEHVAQLLTGSPELKLQFSNDIYSTYNLFPPRHLSDIKTTVVYPATEKHLQKYMRQDLRLIRETGDDYRTITLPYLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILREGQEAILKRYQVTGDRLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAQVIENLECDPKHYQQRTLTFALRTDDPLLQLLQKAQQERN 338 secondary structure helix 101 110 secondary structure helix 132 136 secondary structure helix 147 155 secondary structure helix 165 172 secondary structure helix 172 179 secondary structure helix 184 192 secondary structure helix 196 200 secondary structure helix 223 226 secondary structure helix 240 244 secondary structure helix 245 247 secondary structure helix 248 268 secondary structure helix 270 272 secondary structure helix 309 319 secondary structure helix 321 326 secondary structure helix 336 349 secondary structure strand 59 67 secondary structure strand 72 78 secondary structure strand 90 97 secondary structure strand 114 120 secondary structure strand 124 130 secondary structure strand 138 143 secondary structure strand 159 164 secondary structure strand 202 204 secondary structure strand 211 215 secondary structure strand 228 233 secondary structure strand 274 279 secondary structure strand 288 293 secondary structure strand 306 308 secondary structure strand 328 333 pfam PF11969 Scavenger mRNA decapping enzyme C-term binding 173 291 Indirect evidence Only some parts of the structure participates in mutual synergistic folding. Scavenger mRNA decapping enzyme (DcpS) Multidomain structure, where the domain-swapped N-terminal domain is responsible for dimerization. The extensive interface, symmetry, topology, beta sheet augmentation and buried surface area suggest that the N-terminal dimerization domain behaves as a single rigid domain and the monomers would not be stable on their own. Gel-filtration chromatography also suggested a dimeric form (PMID:15068804). A N/A B N/A MF7000822 MF7000823 MF7000824 MF7000825 MF7000826 MF7000827 MF7000828 MF7000829