{"entry": {"accession": "MF7001002", "general": {"name": "Ureidoglycolate hydrolase (AllA) (Escherichia coli O157:H7)", "pdb_id": "1yqc", "exp_method": "X-ray", "resolution": "1.71", "assembly": "Homodimer", "source_organism": "Escherichia coli O157:H7", "publication": {"pmid": "16114032", "authors": "Raymond S, Tocilj A, Ajamian E, Li Y, Hung MN, Matte A, Cygler M", "title": "Crystal structure of ureidoglycolate hydrolase (AllA) from Escherichia coli O157:H7.", "journal": "Proteins", "year": "2005", "issue": "2", "volume": "61", "pages": "454-9"}}, "function": {"molecular_function": {"go": [{"accession": "GO:0004848", "name": "ureidoglycolate hydrolase activity"}, {"accession": "GO:0050385", "name": "ureidoglycolate lyase activity"}]}, "biological_process": {"go": [{"accession": "GO:0000256", "name": "allantoin catabolic process"}, {"accession": "GO:0006145", "name": "purine nucleobase catabolic process"}]}}, "macromolecules": {"general": {"nr_of_chains": "2", "nr_of_unique_protein_segments": "1", "class": "Homooligomeric enzymes", "subclass": "Homodimeric enzymes", "note": "All chains according to the most probable oligomerization state stored in PDBe were considered."}, "chain": [{"id": "A", "name": "Ureidoglycolate lyase", "source_organism": "Escherichia coli O157:H7", "uniprot": {"id": "P63486", "start": "1", "end": "160", "coverage": "100%", "sequence": "MKLQVLPLSQEAFSAYGDVIETQQRDFFHINNGLVERYHDLALVEILEQDRTLISINRAQPANLPLTIHELERHPLGTQAFIPMKGEVFVVVVALGDDKPDLSTLRAFITNGEQGVNYHRNVWHHPLFAWQRVTDFLTIDRGGSDNCDVESIPEQELCFA", "length": "160"}, "regions": {"region": [{"region_type": "secondary structure", "region_name": "helix", "region_start": "9", "region_end": "14"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "48", "region_end": "51"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "2", "region_end": "7"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "17", "region_end": "20"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "27", "region_end": "30"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "35", "region_end": "43"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "53", "region_end": "59"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "67", "region_end": "73"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "79", "region_end": "83"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "90", "region_end": "94"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "106", "region_end": "109"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "115", "region_end": "118"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "123", "region_end": "124"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "134", "region_end": "140"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "148", "region_end": "158"}, {"region_type": "pfam", "region_id": "PF04115", "region_name": "Ureidoglycolate lyase", "region_start": "2", "region_end": "154"}]}}, {"id": "B", "name": "Ureidoglycolate lyase", "source_organism": "Escherichia coli O157:H7", "uniprot": {"id": "P63486", "start": "1", "end": "160", "coverage": "100%", "sequence": "MKLQVLPLSQEAFSAYGDVIETQQRDFFHINNGLVERYHDLALVEILEQDRTLISINRAQPANLPLTIHELERHPLGTQAFIPMKGEVFVVVVALGDDKPDLSTLRAFITNGEQGVNYHRNVWHHPLFAWQRVTDFLTIDRGGSDNCDVESIPEQELCFA", "length": "160"}, "regions": {"region": [{"region_type": "secondary structure", "region_name": "helix", "region_start": "9", "region_end": "14"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "101", "region_end": "105"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "2", "region_end": "7"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "17", "region_end": "20"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "27", "region_end": "30"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "35", "region_end": "43"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "53", "region_end": "59"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "67", "region_end": "73"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "79", "region_end": "83"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "90", "region_end": "94"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "106", "region_end": "109"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "115", "region_end": "118"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "123", "region_end": "124"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "134", "region_end": "140"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "148", "region_end": "158"}, {"region_type": "pfam", "region_id": "PF04115", "region_name": "Ureidoglycolate lyase", "region_start": "2", "region_end": "154"}]}}]}, "evidence": {"evidence_level": "Indirect evidence", "evidence_coverage": "The full structure participates in mutual synergistic folding.", "sequence_domain": "-", "complex_evidence": "Domain-swapped dimer with beta sheet augmentation and an extensive interface. Face-to-face interactions of 5-stranded b-sheets of the two monomers. Both monomers contribute to the putative active site (PMID:16114032).", "chain_evidence": [{"chain_id": "A", "support": "N/A"}, {"chain_id": "B", "support": "N/A"}]}}}