{"entry": {"accession": "MF7000760", "general": {"name": "Catechol 1,2-dioxygenase with catechol (Acinetobacter sp. ADP 1)", "pdb_id": "1dlt", "exp_method": "X-ray", "resolution": "1.90", "assembly": "Homodimer", "source_organism": "Acinetobacter baylyi", "publication": {"pmid": "10801478", "authors": "Vetting MW, Ohlendorf DH", "title": "The 1.8 A crystal structure of catechol 1,2-dioxygenase reveals a novel hydrophobic helical zipper as a subunit linker.", "journal": "Structure", "year": "2000", "issue": "4", "volume": "8", "pages": "429-40"}}, "function": {"molecular_function": {"go": [{"accession": "GO:0018576", "name": "catechol 1,2-dioxygenase activity"}, {"accession": "GO:0008199", "name": "ferric iron binding"}]}, "biological_process": {"go": [{"accession": "GO:0042952", "name": "beta-ketoadipate pathway"}, {"accession": "GO:0019614", "name": "catechol-containing compound catabolic process"}]}}, "macromolecules": {"general": {"nr_of_chains": "2", "nr_of_unique_protein_segments": "1", "class": "Homooligomeric enzymes", "subclass": "Homodimeric enzymes", "note": "All chains according to the most probable oligomerization state stored in PDBe were considered."}, "chain": [{"id": "A", "name": "Catechol 1,2-dioxygenase", "source_organism": "Acinetobacter baylyi", "uniprot": {"id": "P07773", "start": "3", "end": "311", "coverage": "99%", "sequence": "MEVKIFNTQDVQDFLRVASGLEQEGGNPRVKQIIHRVLSDLYKAIEDLNITSDEYWAGVAYLNQLGANQEAGLLSPGLGFDHYLDMRMDAEDAALGIENATPRTIEGPLYVAGAPESVGYARMDDGSDPNGHTLILHGTIFDADGKPLPNAKVEIWHANTKGFYSHFDPTGEQQAFNMRRSIITDENGQYRVRTILPAGYGCPPEGPTQQLLNQLGRHGNRPAHIHYFVSADGHRKLTTQINVAGDPYTYDDFAYATREGLVVDAVEHTDPEAIKANDVEGPFAEMVFDLKLTRLVDGVDNQVVDRPRLAV", "length": "311"}, "regions": {"region": [{"region_type": "secondary structure", "region_name": "helix", "region_start": "8", "region_end": "19"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "27", "region_end": "48"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "51", "region_end": "68"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "70", "region_end": "78"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "79", "region_end": "95"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "206", "region_end": "215"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "270", "region_end": "277"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "111", "region_end": "112"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "116", "region_end": "118"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "120", "region_end": "122"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "133", "region_end": "141"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "152", "region_end": "156"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "179", "region_end": "183"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "189", "region_end": "195"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "224", "region_end": "230"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "237", "region_end": "243"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "262", "region_end": "263"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "266", "region_end": "268"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "283", "region_end": "287"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "290", "region_end": "291"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "309", "region_end": "310"}, {"region_type": "pfam", "region_id": "PF04444", "region_name": "Catechol dioxygenase N terminus", "region_start": "27", "region_end": "94"}]}}, {"id": "B", "name": "Catechol 1,2-dioxygenase", "source_organism": "Acinetobacter baylyi", "uniprot": {"id": "P07773", "start": "3", "end": "311", "coverage": "99%", "sequence": "MEVKIFNTQDVQDFLRVASGLEQEGGNPRVKQIIHRVLSDLYKAIEDLNITSDEYWAGVAYLNQLGANQEAGLLSPGLGFDHYLDMRMDAEDAALGIENATPRTIEGPLYVAGAPESVGYARMDDGSDPNGHTLILHGTIFDADGKPLPNAKVEIWHANTKGFYSHFDPTGEQQAFNMRRSIITDENGQYRVRTILPAGYGCPPEGPTQQLLNQLGRHGNRPAHIHYFVSADGHRKLTTQINVAGDPYTYDDFAYATREGLVVDAVEHTDPEAIKANDVEGPFAEMVFDLKLTRLVDGVDNQVVDRPRLAV", "length": "311"}, "regions": {"region": [{"region_type": "secondary structure", "region_name": "helix", "region_start": "8", "region_end": "19"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "27", "region_end": "48"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "51", "region_end": "68"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "70", "region_end": "78"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "79", "region_end": "95"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "206", "region_end": "215"}, {"region_type": "secondary structure", "region_name": "helix", "region_start": "270", "region_end": "277"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "111", "region_end": "112"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "116", "region_end": "118"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "120", "region_end": "122"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "133", "region_end": "141"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "152", "region_end": "156"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "179", "region_end": "183"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "189", "region_end": "195"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "224", "region_end": "230"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "237", "region_end": "243"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "262", "region_end": "263"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "266", "region_end": "268"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "283", "region_end": "287"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "290", "region_end": "291"}, {"region_type": "secondary structure", "region_name": "strand", "region_start": "309", "region_end": "310"}, {"region_type": "pfam", "region_id": "PF04444", "region_name": "Catechol dioxygenase N terminus", "region_start": "27", "region_end": "94"}]}}]}, "evidence": {"evidence_level": "Indirect evidence", "evidence_coverage": "Only some parts of the structure participates in mutual synergistic folding.", "sequence_domain": "Dioxygenase", "complex_evidence": "A 'helical zipper', consisting of five N-terminal helices and one extending from the catalytic domain from each subunit forms the dimer interafce, termed linker domain. Helices 4 and 5 lie against the catalytic domain, and helix 4 even donates some residues to the active-site cavity (PMID:10801478).", "chain_evidence": [{"chain_id": "A", "support": "N/A"}, {"chain_id": "B", "support": "N/A"}]}, "related_structures": {"id": ["MF7000760", "MF7000761", "MF7000762", "MF7000763", "MF7000764", "MF7000765", "MF7000766", "MF7000767", "MF7000768", "MF7000769", "MF7000770", "MF7000771"]}}}